Kayron

Echo of Futility I: The base damage on Echo gets a significant buff and you now make 3 futility per Echo. The base damage on this will be superior to Echo V up until 1-3 turns of futility made, on top of scaling your Black-Hole much faster so it is generally superior to Echo V (the go-to option) in low-turn / OTK content, if you can afford its 1AP cost.

Echo of Futility II: Echo now scales at a rate of 20% per futility exhausted. Comparing this to Echo V, it will be superior in damage, assuming you are exhausting every futility, up until 21 futility exhausted. Which means for most content, this will be a superior damage option but lacks the significant QoL of being 0-cost making it harder to play.

Echo of Futility III: Echo’s Futility created now gains [Ephemeral], which automatically exhausts it if it is in hand at the end of the turn. This effectively makes the cost of exhausting both Futility 1 AP (or 0 with Cost Reduction), instead of the 2 to play them manually. This can allow for much easier set-ups to scale your Black Hole faster.

Echo of Futility IV: Echo is now X-cost, which means it takes your current AP and gains additional effects based on AP spent. In this case, it gains the effects of making futility equal to your AP spent +1 meaning it can theoretically make you up to 10 futility (an entire hand). In the current balance of the game, X-costs tend to be rather weak and hard to play around. On-top of the fact that this card has the distinct disadvantage of making you a lot of futility that you need AP to exhaust, but using all the AP you would use to exhaust it. That being said, it was recently buffed to do more damage and we did see a boss (Rita’s Great-Rift) that X-cost attacks, like this, were useful against.

Echo of Futility V: The card is now 0-cost and scales its base ratio at a rate of 30% per futility made, infinitely, but has a very low initial base ratio of 30% (36% with Potentials). For most existing content, this is the go-to Epiphany. It can scale to a higher level quite fast compared to most Epiphanies (only being worse than Echo II until you make exhaust more than 21 futility, or if you are not exhausting the futility for some reason). Moreover, its base 0-cost makes it much easier to play around because of Kayron’s very high AP requirements. It was also buffed recently to start at a much higher ratio than it previously did (effectively + 4 futility created from previous iteration).

Neutral: Target Neutral Epiphany: N/A.
The Neutral epiphany access of Psionics isn't particularly beneficial to Kayron.

Divine: Which Divine Epiphany to go for will depend on what your team needs and which Epiphany you chose, but here are the main ones to look out for if you have spare Save Data: -1 Cost Reduction, Vulnerable 2, 1 AP (Echo V).

Brand of Annihilation I: Brand now has a significantly higher ratio, but otherwise the same effects. This is generally the go-to for most builds pre-E1 Kayron, as it is hard to quickly exhaust the needed amount of cards for Brand III without E1.

Brand of Annihilation II: Brand now does 2-hits, but is no longer AOE. This is one of Kayron’s best Epiphanies for single-target damage, with it being a high ratio 2-hit combo. However, Kayron generally uses his Brand more for AOE scenarios, so this is less of a universal choice.

Brand of Annihilation III: Brand is now 7-cost but will permanently reduce its cost for every Futility card exhausted in the current battle. While this is definitely the go-to for E1+ Kayron, it can be hard to exhaust the needed amount quickly, without it making it slightly less of a universal choice for recommendations.

Brand of Annihilation IV: Brand is now always 1-cost but can scale its damage for any card exhausted, including allies, by +40%. It has the highest damage potential of any brand, but requires you to exhaust a very high number of cards to reach it. Generally speaking, it will not be used outside of OTK but is his premiere card for T1 OTK-based builds, as there are a lot of ways to exhaust many cards in one turn, but fewer ways to do so consistently.

Brand of Annihilation V: Brand is now always 2-cost, but it gains 3 Agony application if a card was exhausted. This is flat-out worse than Neutral Epiphanies, which will give you 4 Agony and enable you to still reduce the Brand cost to 0, making it not recommended in the slightest–even if you were building for Agony application.

Neutral: Target Neutral Epiphany: Morale 4.
If, for some reason, you want to play buffer Kayron, he can theoretically be one of the best buffers in the game, as with 3 [Exhausts], you can make Brand 0-cost for that turn and give 4 Morale for every Brand you play. That being said, he is generally never used in a more Supportive/Buffing playstyle and the Morale buff from this does not synergize well with Kayron’s own kit.

Divine: Which Divine Epiphany to go for will depend on what your team needs and which Epiphany you chose, but here are the main ones to look out for if you have spare Save Data: Weakness Attack, Vulnerable 2, 30% Damage Increase.

Black Hole I: Black Hole will activate 2 Futility on use, but gains its scaling effect. This essentially is trading 2 AP to save 2 AP (and gain 1 Additional Hit but lose 1 Draw), when you could instead delete Black Hole and just play the 2 Futilities manually at that point. Moreover, it just has much worse damage Potential in the long run because it lacks the infinite scaling of the base Brand or Brand II.

Black Hole II: Black Hole gains a higher base ratio and now scales at a higher rate of +60% per Futility exhausted. The go-to option for any scaling-based build, which is typically where Black-Hole matters most.

Black Hole III: It has much worse damage potential in the long run because it lacks the infinite scaling of the Base Black Hole or Black Hole II.

Black Hole IV: It has much worse damage potential in the long run because it lacks the infinite scaling of the Base Black Hole or Black Hole II.

Black Hole V: Black Hole now adds additional Fixed Damage for every Futility exhausted. Some builds that do not play Black Hole or cannot afford to (like OTK setups with Brand IV) will choose to take this simply to easily get rid of it. However, it has much worse damage Potential in the long run because it lacks the infinite scaling of the Base Brand or Brand II.

Neutral: The Neutral Epiphany access on this card tends to bring very little value to Kayron; however, it can be worth considering simply because the base card can be better in scaling-based builds than other options.

Divine: Which Divine Epiphany to go for will depend on what your team needs and which Epiphany you chose, but here are the main ones to look out for if you have spare Save Data: Weakness Attack, Vulnerable 2, 30% Damage Increase.

Oath of Vanity I: The card is now 0-cost and gains [Initiation]. This can be a great option if you want consistent activation for an attack Futility-based build.

Oath of Vanity II: The base values of Futility change from 100%DMG/100%HEAL to 150%DMG/150%HEAL. For attack Futility, this is the best option for healing, so it is preferred if you need the extra survivability.

Oath of Vanity III: The heal effect is removed and it now does 200% base damage. For attack Futility, this is the best option for damage, so it is preferred if you want the extra damage in a build where you use attack Futility.

Oath of Vanity IV: This exhausts a large number of Status Ailments/Futility once for free, usually on Turn 1 and gives you draw for all exhausted cards. If you are unsure of what to build, this is the go-to option since it will get high value in all content. Even in builds where you would prefer to attack Futility, it tends to perform well still, as you can rely on Supportive builds to circumvent the loss in survivability and get value out of this Epiphany’s strong Turn 1.

Oath of Vanity V: This is an option if you just want to get rid of the Epiphany or avoid using attacks, but aren’t offered Oath IV. In Season 2’s Great Rift, this has seen some play for precisely that, as hitting enemies directly can be a detriment; however, it is strictly worse than Oath IV at doing this job, as it doesn’t give as strong of utility since the additional Agony damage is completely negligible and Kayron seldom runs a 2P Agony Set.

Neutral: Target Neutral Epiphany: N/A.
There is no specific Epiphany that you are aiming for, but the base Epiphany card can be preferred over certain other options. For example, this could be preferred over Oath IV if you want to use Active Futility (Futility attacks) or it could be preferred over Oath III if you want to keep the extra healing. That being said, even in scenarios where it can be preferred over other options, it will still typically be preferred to take another option like Oath II or Oath I.

Divine: Divine Epiphanies provide negligible value on this card; therefore, an Epiphany that synergizes with your build should be prioritized over Divines.